Curcumin for treatment of oral submucous fibrosis

Tumeric, curcumin

This review of the efficacy of curcumin in improving symptoms in patients with oral submucous fibrosis (OSF) included 13 RCTs. The main findings suggest no significant difference between curcumin and controls although the studies are small and heterogenous.

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Oral submucous fibrosis and malignant transformation

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This umbrella review of the proportion of oral cancer development in oral submucous fibrosis patients included 4 systematic reviews published between 2019 and 2022. Mean values for malignant transformation across the reviews range from 4.2% to 6%.

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Oral submucous fibrosis – malignant transformation rate

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In this blog we look at a review of the malignant transformation rate (MTR) for oral submucous fibrosis (OSF). The review included 16 studies estimating the malignant transformation rate as 6% (95%CI: 2% to 10%)

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Salivary lactate dehydrogenase in oral and potential malignant disorders

Study findings suggest a number of uses for visual aid support of Thickness Indicator Model tubes

In her first Dental Elf blog Iris Vaid looks at a review of salivary lactate dehydrogenase (LDH) as a potential diagnostic marker for oral cancer and oral potentially malignant disorders.

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Oral examination for detecting oral cancer

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This review of the diagnostic accuracy of visual inspection compared with biopsy (gold standard) for the diagnosis or oral cancer and oral potentially malignant dissorders included 18 studies. For malignant lesions the pooled sensitivity was 88% (95%CI; 73% to 95%) and specificity 81%(95%CI; 51% to 95%).

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Human Papilloma Virus in oral potentially malignant disorders

Human Papilloma Virus

In this blog Manás Dave looks at a review of the prevalence of human papilloma virus (HPV) in oral potentially malignant disorders (OPMD). Although 52 studies were included one in five OPMDs being HPV positive is not a substantial link so teh findings need to be interpreted cautiously.

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Oral submucous fibrosis: Is treatment with hyaluronidase and corticosteroids effective?

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This review of the efficacy of hyaluronidase combined with corticosteroids in the management of oral submucous fibrosis (OSF)included 6 small RCTs of short duration. Only one of the RCTs was considered to be at low risk of bias so additional well conducted and reported studies with larger sample are needed to evaluate treatments for OSF.

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Curcumin for management of oral submucous fibrosis

Tumeric, curcumin

This review evaluating the evidence on the effectiveness of curcumin in the management of oral submucous fibrosis included 6 small RCTs providing inconclusive evidence of a potential benefit.

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Aloe vera for treatment of oral submucous fibrosis?

shutterstock_32414035 - Betel leaf

This review effectiveness of aloe vera on alleviating the symptoms of oral submucous fibrosis included 6 RCTs . The findings suggest a possible benefit but 5 of the trials were at high risk of bias so the findings should be viewed cautiously.

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Oral potentially malignant disorders – how common are they?

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This review of the prevalence of oral potentially malignant disorders included 22 observational studies providing a pooled estimate for prevalence of 4.47% (95% CI;2.43-7.08).

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