Articaine v lidocaine for third molar removal

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This review comparing the effectiveness of articaine and lidocaine for lower third molar surgery included 14 RCTs. The findings suggest that articaine is superior to lidocaine for use in lower third molar however the available are small so additional larger high quality studies would be helpful to strengthen the evidence.

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Articaine-adverse effects in paediatric dental patients

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This review of the effects and adverse reactions between articaine and lidocaine in paediatric dental procedures included 8 RCTS. Three of the included studies were at high risk of bias 2 at low risk and 3 at unclear risk. The findings suggested no difference in adverse effects between the two anaesthetics with the certainty of evidence being assessed as moderate.

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Understanding maladaptive exercise in adolescence: who is at risk and why?

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Caroline Touzeau and Caitlin Lloyd blog about a recent longitudinal cohort study that investigated patterns of maladaptive exercise in young people, which supports “re-framing motivations for exercise in youth away from weight loss at a population level”.

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High-fluoride toothpaste or high fluoride mouthrinse to prevent white spot lesions in adolescent orthodontic patients – trial

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270 pateints were randomised in this trial to compare high-fluoride toothpaste and high-fluoride mouth rinse for preventing white spot lesions during orthodontic treatment. The findings suggest a benefit for high fluoride toothpaste and fluoride mouth rinse in preventing white spot lesions.

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Psilocybin for ‘treatment-resistant depression’: an island of hope in an ocean of uncertainty?

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In this blog, UCL MSc students consider an RCT published in the New England Journal of Medicine, which suggests that psilocybin-assisted psychotherapy may help reduce depression in people with severe and enduring illness, but side effects are common and more research is needed to look into longer term effects.

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Orthodontic space closure after tooth extraction- early or delayed?

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This review of early versus delayed initiation of space closure after tooth extraction on the rate of orthodontic tooth movement included 11 RCTs. The findings suggest little difference between the two approaches but the included studies are small and none of the theam are at low risk of bias.

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Antidepressants, cognition, and emotional blunting: what’s the evidence?

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Angharad de Cates reviews a recent Danish trial, which finds that escitalopram reduced participants’ reinforcement sensitivity compared to those on placebo. This lower reinforcement sensitivity may be similar to the emotional blunting effect often reported by patients during SSRI treatment.

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Inferior alveolar nerve block 2% mepivacaine versus 4% articaine – trial

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This well conducted randomised controlled trial assessed inferior alveolar nerve block (IANB) success of 2% mepivacaine and 4% articaine in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars during access cavity preparation and instrumentation.

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Nicotine replacement therapy – oral side effects

For inpatients with psychiatric symptoms of moderate severity, the study suggests those using nicotine inhalers were most successful overall in their quit attempts. There were no severe adverse reactions to the NRTs.

This review of the evidence on possible association between locally delivered nicotine replacement therapy(NRT) and oral side effects included 28 RCTs. Most of the RCTs were at high risk of bias mainly because of allocation concealment concerns. Reported oral side effects including oral soreness, gastric reflux or vomiting, and mouth or throat irritation.

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Mindfulness in schools: MYRIAD trial findings offer limited support for school based mindfulness training

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Lucinda Powell reports on the findings of the huge MYRIAD (My Resilience in Adolescence) project, which looked at the effectiveness of school based mindfulness training across more than 100 UK schools.

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